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Intra-protein binding peptide fragments have specific and intrinsic sequence patterns

By Yuhong Wang, Junzhou Huang, Wei Li, Sheng Wang, Chuanfan Ding

Posted 31 Mar 2017
bioRxiv DOI: 10.1101/122978 (published DOI: 10.1038/s41598-017-14877-w)

The key finding in the DNA double helix model is the specific pairing or binding between nucleotides A-T and C-G, and the pairing rules are the molecule basis of genetic code. Unfortunately, no such rules have been discovered for proteins. Here we show that similar rules and intrinsic sequence patterns between intra-protein binding peptide fragments do exist, and they can be extracted using a deep learning algorithm. Multi-millions of binding and non-binding peptide fragments from currently available protein X-ray structures are classified with an accuracy of up to 93%. This discovery has the potential in helping solve protein folding and protein-protein interaction problems, two open and fundamental problems in molecular biology.

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