Rxivist logo

An open-source platform to distribute and interpret data from multiplexed assays of variant effect

By Daniel Esposito, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P Roth, Douglas M. Fowler, Alan F Rubin

Posted 21 Feb 2019
bioRxiv DOI: 10.1101/555797 (published DOI: 10.1186/s13059-019-1845-6)

Multiplex Assays of Variant Effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single experiment. Despite the importance of MAVE data for basic and clinical research, there is no standard resource for their discovery and distribution. Here we present MaveDB, a public repository for large-scale measurements of sequence variant impact, designed for interoperability with applications to interpret these datasets. We also describe the first of these applications, MaveVis, which retrieves, visualizes, and contextualizes variant effect maps. Together, the database and applications will empower the community to mine these powerful datasets.

Download data

  • Downloaded 744 times
  • Download rankings, all-time:
    • Site-wide: 18,171 out of 89,274
    • In genomics: 2,215 out of 5,695
  • Year to date:
    • Site-wide: 51,475 out of 89,274
  • Since beginning of last month:
    • Site-wide: 37,207 out of 89,274

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)