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Structure of the Ebola virus nucleoprotein - RNA complex

By Robert N. Kirchdoerfer, Erica O. Saphire, Andrew Ward

Posted 13 Feb 2019
bioRxiv DOI: 10.1101/548313 (published DOI: 10.1107/S2053230X19004424)

Ebola virus is an emerging virus capable of causing a deadly disease in humans. Replication, transcription and packaging of the viral genome is carried out by the viral nucleocapsid. The nucleocapsid is a complex of the viral nucleoprotein, RNA and several other viral proteins. The nucleoprotein NP forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. The 3.1 angstrom single-particle cryo-electron microscopy structure of the nucleoprotein-RNA helical filament presented here resembles previous structures determined at lower resolution while providing improved molecular details of protein-protein and protein-RNA interactions. The higher resolution of the structure presented here will facilitate the design and characterization of novel and specific Ebola virus therapeutics targeting the nucleocapsid.

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