Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 59,744 bioRxiv papers from 265,577 authors.

Cusp-artifacts in high order superresolution optical fluctuation imaging

By Xiyu Yi, Shimon Weiss

Posted 10 Feb 2019
bioRxiv DOI: 10.1101/545574 (published DOI: 10.1016/j.bpj.2018.11.739)

Superresolution optical fluctuation imaging (SOFI) is a simple and affordable super-resolution imaging technique and attracted a growing community over the past decade. However, the theoretical resolution enhancement of high order SOFI is still not fulfilled. In this study, we have identified "cusp artifacts" for the first time in high order SOFI images, and have shown that the high-order cumulants, odd-order moments and balanced-cumulants (bSOFI) are highly vulnerable to cusp artifacts. Our study provides guidelines for developing and screening for fluorescence probes and improving data acquisition for SOFI. The new insight is important to inspire positive utilization of the cusp artifacts.

Download data

  • Downloaded 220 times
  • Download rankings, all-time:
    • Site-wide: 39,410 out of 59,758
    • In bioengineering: 707 out of 1,158
  • Year to date:
    • Site-wide: 15,154 out of 59,758
  • Since beginning of last month:
    • Site-wide: 12,238 out of 59,758

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)