Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,960 bioRxiv papers from 321,862 authors.

Cusp-artifacts in high order Superresolution optical fluctuation imaging

By Xiyu Yi, Shimon Weiss

Posted 10 Feb 2019
bioRxiv DOI: 10.1101/545574 (published DOI: 10.1016/j.bpj.2018.11.739)

Superresolution optical fluctuation imaging (SOFI) is a simple and affordable super-resolution imaging technique, and attracted a growing community over the past decade. However, the theoretical resolution enhancement of high order SOFI is still not fulfilled. In this study, we identify “cusp artifacts” in high order SOFI images, and show that the high-order cumulants, odd-order moments and balanced-cumulants (bSOFI) are highly vulnerable to cusp artifacts. Our study provides guidelines for developing and screening for fluorescence probes, and improving data acquisition for SOFI. The new insight is important to inspire positive utilization of the cusp artifacts.

Download data

  • Downloaded 326 times
  • Download rankings, all-time:
    • Site-wide: 38,454 out of 73,960
    • In bioengineering: 722 out of 1,538
  • Year to date:
    • Site-wide: 35,979 out of 73,960
  • Since beginning of last month:
    • Site-wide: 35,979 out of 73,960

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)