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Cusp-artifacts in high order superresolution optical fluctuation imaging

By Xiyu Yi, Shimon Weiss

Posted 10 Feb 2019
bioRxiv DOI: 10.1101/545574 (published DOI: 10.1016/j.bpj.2018.11.739)

Superresolution optical fluctuation imaging (SOFI) is a simple and affordable super-resolution imaging technique and attracted a growing community over the past decade. However, the theoretical resolution enhancement of high order SOFI is still not fulfilled. In this study, we have identified "cusp artifacts" for the first time in high order SOFI images, and have shown that the high-order cumulants, odd-order moments and balanced-cumulants (bSOFI) are highly vulnerable to cusp artifacts. Our study provides guidelines for developing and screening for fluorescence probes and improving data acquisition for SOFI. The new insight is important to inspire positive utilization of the cusp artifacts.

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