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SwiftOrtho: a Fast, Memory-Efficient, Multiple Genome Orthology Classifier

By Xiao Hu, Iddo Friedberg

Posted 08 Feb 2019
bioRxiv DOI: 10.1101/543223

Introduction: Gene homology type classification is a requisite for many types of genome analyses, including comparative genomics, phylogenetics, and protein function annotation. A large variety of tools have been developed to perform homology classification across genomes of different species. However, when applied to large genomic datasets, these tools require high memory and CPUusage, typically available only in costly computational clusters. To address this problem, we developed a new graph-based orthology analysis tool, SwiftOrtho,which is optimized for speed and memory usage when applied to large-scale data. Results: In our tests, SwiftOrtho is the only tool that completed orthology analysis of 1,760 bacterial genomes on a computer with only 4GBRAM. Using various standard orthology datasets, we also show that SwiftOrtho has a high accuracy. SwiftOrtho enables the accurate comparative genomic analyses of thousands of genomes using low memory computers. Availability: https://github.com/Rinoahu/SwiftOrtho

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