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A genetically-encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling

By David L. Prole, Colin W Taylor

Posted 08 Feb 2019
bioRxiv DOI: 10.1101/544700 (published DOI: 10.1186/s12915-019-0662-4)

Background Intrabodies enable targeting of proteins in live cells, but generating specific intrabodies against the thousands of proteins in a proteome poses a challenge. We leverage the widespread availability of fluorescently labelled proteins to visualize and manipulate intracellular signalling pathways in live cells by using nanobodies targeting fluorescent protein tags.

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