Life history recorded in the vagino-cervical microbiome
Posted 30 Jan 2019
bioRxiv DOI: 10.1101/533588
Posted 30 Jan 2019
The vagina contains at least a billion microbial cells, which are dominated by Lactobacilli. Here we perform metagenomic shotgun sequencing on cervical samples from 1148 women. Factors such as pregnancy, delivery histories and breast-feeding were all more important than menstrual cycle in shaping the microbiome. Bifidobacterium breve was seen with older age at sexual debut; Lactobacillus crispatus negatively correlated with pregnancy history; potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, contraceptives were also identified. Other features such as mood fluctuations and facial speckles could potentially be deduced from the vagino-cervical microbiome. Gut and oral microbiome, plasma vitamins, metals, amino acids and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact. Highlights Shotgun sequencing of 1148 vagino-cervical samples reveal subtypes; Other omics such as moods and skin features could be predicted by the vagino-cervical bacteria; Factors such as delivery mode and breast-feeding associate with the vagino-cervical microbiome; With dwindled Lactobacilli, postmenopausal samples are relatively enriched for viruses.
- Downloaded 1,171 times
- Download rankings, all-time:
- Site-wide: 16,638
- In microbiology: 946
- Year to date:
- Site-wide: 42,411
- Since beginning of last month:
- Site-wide: 36,307
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!