Prognostic signature is important in estimating cancer risk, subtyping cancer, and planning treatment. A single gene as a prognostic marker would facilitate the development of a clinical test. Here we showed that the number of prognostic and diagnostic genes differ greatly across cancers. By considering both the survival difference and the fold change of expression in cancer, we revealed the prognostic genes for each cancer and found twenty two genes with both diagnostic and prognostic capacity. The universal prognostic genes (CDC20, CDCA8, ASPM, ERCC6L, and GTSE1) mainly function in the spindle assembly checkpoint, and show more statistical links to mutated pathways, suggesting that expression of these genes can be altered by mutations from many pathways. Briefly, we systematically identified the prognostic genes and revealed the associations between the prognostic genes and genes mutated in cancer. Keywords: Prognostic gene; Cancer; Mutation; Diagnosis
- Downloaded 438 times
- Download rankings, all-time:
- Site-wide: 88,226
- In cancer biology: 2,610
- Year to date:
- Site-wide: 90,469
- Since beginning of last month:
- Site-wide: 69,197
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!