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Ultrafast comparison of personal genomes

By Gustavo Glusman, Denise Mauldin, Leroy Hood, Max Robinson

Posted 27 Jun 2017
bioRxiv DOI: 10.1101/130807 (published DOI: 10.3389/fgene.2017.00136)

We present an ultra-fast method for comparing personal genomes. We transform the standard genome representation (lists of variants relative to a reference) into 'genome fingerprints' that can be readily compared across sequencing technologies and reference versions. Because of their reduced size, computation on the genome fingerprints is fast and requires little memory. This enables scaling up a variety of important genome analyses, including quantifying relatedness, recognizing duplicative sequenced genomes in a set, population reconstruction, and many others. The original genome representation cannot be reconstructed from its fingerprint; the method thus has significant implications for privacy-preserving genome analytics.

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