Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,789 bioRxiv papers from 265,997 authors.

Computational modeling reveals frequency modulation of calcium-cAMP/PKA pathway in dendritic spines

By Donya Ohadi, Danielle L Schmitt, Barbara Calabrese, Shelley Halpain, Jin Zhang, Padmini Rangamani

Posted 16 Jan 2019
bioRxiv DOI: 10.1101/521740

Dendritic spines are the primary excitatory postsynaptic sites that act as subcompartments of signaling. Calcium is often the first and most rapid signal in spines. Downstream of calcium, the cAMP/PKA pathway plays a critical role in the regulation of spine formation, morphological modifications, and ultimately, learning and memory. While the dynamics of calcium are reasonably well-studied, calcium-induced cAMP/PKA dynamics, particularly with respect to frequency modulation, are not fully explored. In this study, we present a well-mixed model for the dynamics of calcium-induced cAMP/PKA dynamics in dendritic spines. The model is constrained using experimental observations in the literature. Further, we measured the calcium oscillation frequency in dendritic spines of cultured hippocampal CA1 neurons and used these dynamics as model inputs. Our model predicts that the various steps in this pathway act as frequency modulators for calcium and the high frequency of calcium input is filtered by AC1 and PDEs in this pathway such that cAMP/PKA only responds to lower frequencies. This prediction has important implications for noise filtering and long-timescale signal transduction in dendritic spines. A companion manuscript presents a three-dimensional spatial model for the same pathway.

Download data

  • Downloaded 327 times
  • Download rankings, all-time:
    • Site-wide: 27,782 out of 57,789
    • In biophysics: 1,067 out of 2,450
  • Year to date:
    • Site-wide: 7,314 out of 57,789
  • Since beginning of last month:
    • Site-wide: 7,512 out of 57,789

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)