Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,690 bioRxiv papers from 320,698 authors.

Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes

By Sarah E. Morgan, Jakob Seidlitz, Kirstie Whitaker, Rafael Romero-Garcia, Nicholas E Clifton, Cristina Scarpazza, Therese van Amelsvoort, Machteld Marcelis, Jim van Os, Gary Donohoe, David Mothersill, Aiden Corvin, Andrew Pocklington, Armin Raznahan, Philip McGuire, The PSYSCAN Consortium, Petra E. VĂ©rtes, Edward T. Bullmore

Posted 19 Dec 2018
bioRxiv DOI: 10.1101/501494 (published DOI: 10.1073/pnas.1820754116)

Schizophrenia has been conceived as a disorder of brain connectivity but it is unclear how this network phenotype is related to the emerging genetics. We used morphometric similarity analysis of magnetic resonance imaging (MRI) data as a marker of inter-areal cortical connectivity in three prior case-control studies of psychosis: in total, N=185 cases and N=227 controls. Psychosis was associated with globally reduced morphometric similarity (MS) in all 3 studies. There was also a replicable pattern of case-control differences in regional MS which was significantly reduced in patients in frontal and temporal cortical areas, but increased in parietal cortex. Using prior brain-wide gene expression data, we found that the cortical map of case-control differences in MS was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms and pathways. In addition, genes that were normally over-expressed in cortical areas with reduced MS were significantly up-regulated in a prior post mortem study of schizophrenia. We propose that this combination of neuroimaging and transcriptional data provides new insight into how previously implicated genes and proteins, as well as a number of unreported proteins in their vicinity on the protein interaction network, may interact to drive structural brain network changes in schizophrenia.

Download data

  • Downloaded 343 times
  • Download rankings, all-time:
    • Site-wide: 36,664 out of 73,690
    • In neuroscience: 6,398 out of 13,249
  • Year to date:
    • Site-wide: 37,280 out of 73,690
  • Since beginning of last month:
    • Site-wide: 37,280 out of 73,690

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)