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Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

By Tobias Kaufmann, Dennis van der Meer, Dag Alnaes, Oleksandr Frei, Olav B. Smeland, Ole A. Andreassen, Lars T. Westlye

Posted 04 Dec 2018
bioRxiv DOI: 10.1101/487173

Neurodevelopmental trajectories are shaped by interactions between coordinated biological processes and individual experiences throughout ontogeny, yet the specific genetic and environmental impact on brain development is enigmatic. Here, we map the genetic architectures of cognitive traits and psychiatric disorders onto the brain, show that such canonical genetic maps are associated with individual normative patterns in youths, and provide evidence that trauma exposure and parental education may alter this relationship.

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