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Plant-Necrotroph Co-transcriptome Networks Illuminate a Metabolic Battlefield

By Wei Zhang, Jason A. Corwin, Daniel Copeland, Julie E Feusier, Robert Eshbaugh, David E Cook, Susana Atwell, Dan Kliebenstein

Posted 04 Dec 2018
bioRxiv DOI: 10.1101/485235 (published DOI: 10.7554/eLife.44279)

A central goal of studying host-pathogen interaction is to understand how host and pathogen manipulate each other to promote their own fitness in a pathosystem. Co-transcriptomic approaches can simultaneously analyze dual transcriptomes during infection and provide a systematic map of the cross-kingdom communication between two species. Here we used the Arabidopsis- B. cinerea pathosystem to test how plant host and fungal pathogen interact at the transcriptomic level. We assessed the impact of genetic diversity in pathogen and host by utilization of a collection of 96 isolates infection on Arabidopsis wild-type and two mutants with jasmonate or salicylic acid compromised immunities. We identified ten B. cinerea gene co-expression networks (GCNs) that encode known or novel virulence mechanisms. Construction of a dual interaction network by combining four host- and ten pathogen-GCNsrevealed potential connections between the fungal and plant GCNs. These co-transcriptome data shed lights on the potential mechanisms underlying host-pathogen interaction.

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