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A macaque connectome for large-scale network simulations in TheVirtualBrain

By Kelly Shen, Gleb Bezgin, Michael Schirner, Petra Ritter, Stefan Everling, Randy McIntosh

Posted 28 Nov 2018
bioRxiv DOI: 10.1101/480905 (published DOI: 10.1038/s41597-019-0129-z)

Models of large-scale brain networks that are informed by the underlying anatomical connectivity contribute to our understanding of the mapping between the structure of the brain and its dynamical function. Connectome-based modelling is a promising approach to a more comprehensive understanding of brain function across spatial and temporal scales, but it must be constrained by multi-scale empirical data from animal models. Here we describe the construction of a macaque connectome for whole-cortex simulations in TheVirtualBrain, an open-source simulation platform. We take advantage of available axonal tract-tracing datasets and enhance the existing connectome data using diffusion-based tractography in macaques. We illustrate the utility of the connectome as an extension of TheVirtualBrain by simulating resting-state BOLD-fMRI data and fitting it to empirical resting-state data.

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