Rxivist logo

Massively parallel profiling of HIV-1 resistance to the fusion inhibitor enfuvirtide

By Adam S. Dingens, Dana Arenz, Julie Overbaugh, Jesse Bloom

Posted 19 Nov 2018
bioRxiv DOI: 10.1101/472746 (published DOI: 10.3390/v11050439)

Resistance to enfuvirtide, the only clinically approved HIV-1 entry inhibitor, has primarily been mapped to the binding site in the N-terminal heptad repeat (NHR) of the Env transmembrane domain and a limited number of allosteric sites. To better delineate the genotypic determinants of resistance, we used deep mutational scanning to quantify how all mutations to HIV-1 Env affect enfuvirtide sensitivity. We identified numerous additional resistance mutations in the NHR and other regions of Env, including the co-receptor binding site. This complete map of resistance sheds light on the diverse mechanisms of enfuvirtide resistance and can inform clinical monitoring of patients.

Download data

  • Downloaded 227 times
  • Download rankings, all-time:
    • Site-wide: 95,506
    • In microbiology: 6,957
  • Year to date:
    • Site-wide: 89,603
  • Since beginning of last month:
    • Site-wide: 89,603

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)