Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,138 bioRxiv papers from 306,359 authors.

APOBEC-mediated DNA alterations: a possible new mechanism of carcinogenesis in EBV-positive gastric cancer

By Irina Bobrovnitchaia, Renan Valieris, Rodrigo Drummond, João Lima, Helano Freitas, Thais Bartelli, Maria Amorin, Diana Nunes, Emmanuel Dias-Neto, Israel Silva

Posted 19 Nov 2018
bioRxiv DOI: 10.1101/473884 (published DOI: 10.1002/ijc.32411)

Mechanisms of viral oncogenesis are diverse and include the off-target activity of enzymes expressed by the infected cells, which evolved to target viral genomes for controlling their infection. Among these enzymes, the single-strand DNA editing capability of APOBECs represent a well-conserved viral infection response that can also cause untoward mutations in host DNA. Here we show , after evaluating somatic single-nucleotide variations and transcriptome data in 240 gastric cancer samples, a positive correlation between APOBEC3s mRNA-expression and the APOBEC-mutation signature, both increased in EBV+ tumors. The correlation was reinforced by the observation of APOBEC-mutations preferentially occuring in transcriptionally-active loci. The EBV-infection and APOBEC3 mutation-signature axis was confirmed in a validation cohort of 112 gastric cancer patients. Our findings suggest that APOBEC3 upregulation in EBV+ cancer may boost the mutation load, providing further clues to the mechanisms of EBV-induced gastric carcinogenesis. After further validation, this EBV-APOBEC axis may prove to be a secondary driving force in the mutational evolution of EBV+ gastric tumors, whose consequences in terms of prognosis and treatment implications should be vetted.

Download data

  • Downloaded 285 times
  • Download rankings, all-time:
    • Site-wide: 40,003 out of 70,138
    • In cancer biology: 1,251 out of 2,382
  • Year to date:
    • Site-wide: 46,246 out of 70,138
  • Since beginning of last month:
    • Site-wide: 21,987 out of 70,138

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News