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Tumors subvert immune cell function to evade immune responses, and the mechanisms of tumor immune evasion are incompletely understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity. Using a novel transgenic fluorescent reporter mouse line we identify and characterize de novo steroidogenic T cells. Genetic ablation of T cell steroidogenesis restricts primary tumor growth and metastatic dissemination in mouse models. Steroidogenic T cells dysregulate anti-tumor immunity, which can be restored by inhibiting the steroidogenesis pathway. This study demonstrates that T cell de novo steroidogenesis is a cause of anti-tumor immunosuppression and a druggable target.

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    • Site-wide: 18,472 out of 66,801
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