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Relationship between epicardial and perivascular fatty tissue and adipokine-cytokine level in coronary artery disease patients

By Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Viktoria Karetnikova, Natalia Brel, Kokov Alexander, Olga Barbarash

Posted 14 Nov 2018
bioRxiv DOI: 10.1101/470872 (published DOI: 10.1371/journal.pone.0208156)

The aim of this study was to determine the relationship between the thickness of EAT and PVAT and the adipokine-cytokine profile of patients with coronary heart disease, which can be of significant importance for predicting the course of CVD. 84 patients with CVD, were assessed and divided into two groups based on the presence of visceral obesity (VO). In VO patients, the thickness of the epicardial deposits of the left and right ventricles were 1.75 and 1.43 times greater, respectively, than in patients without VO. For patients with VO, the prevalence of the volume of the left anterior descending artery was 10% higher, and the middle third of the envelope artery was 28% higher, when compared to patients without VO. When evaluating inflammatory status, it was established that the concentration of TNF-α and IL-1β, leptin in the blood serum of patients with VO exceeded the values of patients without VO. Level of proinflammatory IL-10 was 2-times lower in patients with VO. The findings of this study show that the increase of EAT and PVAT are independent risk factors of CVD, as well as a possible model for the assessment of drug effectiveness for CVD.

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