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Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)

By Taihua Wang, Xing Chen, Xiaohui Cui, Lina Zhao, Zhenzhen Yang, Xin Wang, Bailing Zhang, Meidai Fan, Xinyi Shi, Rongrong Li, Qingchang Fang, Xiaojuan Diao, Limin Zhang, Guoke Yang, Ying Meng, Shoujin Fan, Guiwen Yang, Liguo An, Gang Zhang

Posted 05 Nov 2018
bioRxiv DOI: 10.1101/462127

Insulin is the only hormone to regulate the metabolism of glucose. Currently, exogenous insulin administration is the widely-used standard strategy for human diabetes patients. However, the injection of insulin cannot be a sufficient method to prevent from the progression of the disease and the development of diabetes complications. Here, we investigate an efficient strategy, in which we employ human pluoripotent stem cells to overexpress human insulin or estrogen-related receptor γ (ERRγ) gene. Our new method, in theory, can both repair the damaged tissues and restore the function of human pancreatic β cells, and also synthesize and secrete human insulin into the blood, therefore, to decrease blood glucose levels of the patients via intravenous transplantation. Our preliminary data revealed that this method not only can efficiently secrete human insulin, reduce glycosylated haemoglobin levels, but also improve the patients health conditions physically and mentally. Hence, it may have the potential to prevent and eventually to reverse human diabetic complications. Our reports suggested that this strategy is very promising for eventually curing human diabetes mellitus.

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