Rxivist logo

Genetic Consequences of Social Stratification in Great Britain

By Abdel Abdellaoui, David Hugh-Jones, Kathryn E Kemper, Yan Holtz, Michel G. Nivard, Laura Veul, Loic Yengo, Brendan P. Zietsch, Timothy M. Frayling, Naomi R. Wray, Jian Yang, Karin J.H. Verweij, Peter M. Visscher

Posted 30 Oct 2018
bioRxiv DOI: 10.1101/457515 (published DOI: 10.1038/s41562-019-0757-5)

Human DNA varies across geographic regions, with most variation observed so far reflecting distant ancestry differences. Here, we investigate the geographic clustering of genetic variants that influence complex traits and disease risk in a sample of ~450,000 individuals from Great Britain. Out of 30 traits analyzed, 16 show significant geographic clustering at the genetic level after controlling for ancestry, likely reflecting recent migration driven by socio-economic status (SES). Alleles associated with educational attainment (EA) show most clustering, with EA-decreasing alleles clustering in lower SES areas such as coal mining areas. Individuals that leave coal mining areas carry more EA-increasing alleles on average than the rest of Great Britain. In addition, we leveraged the geographic clustering of complex trait variation to further disentangle regional differences in socio-economic and cultural outcomes through genome-wide association studies on publicly available regional measures, namely coal mining, religiousness, 1970/2015 general election outcomes, and Brexit referendum results.

Download data

  • Downloaded 9,072 times
  • Download rankings, all-time:
    • Site-wide: 1,563
    • In genetics: 33
  • Year to date:
    • Site-wide: 6,622
  • Since beginning of last month:
    • Site-wide: 7,811

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide