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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

By Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M Yiorkas, Ibrahim Karaman, Joshua Elliott, Stefanie Aeschbacher, Traci M Bartz, Sebastian E Baumeister, Peter S. Braund, Michael R Brown, Jennifer A Brody, Toni-Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A Kentistou, Peter K Joshi, Rozenn N. Lemaitre, Penelope A Lind, Leo-Pekka Lyytikainen, Massimo Mangino, Yuri Milaneschi, Christopher P Nelson, Ilja M. Nolte, Mia-Maria Perala, Ozren Polasek, David Porteous, Scott M Ratliff, Jennifer A. Smith, Alena Stancakova, Alexander Teumer, Samuli Tuominen, Sebastien Theriault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E Arking, Juha Auvinen, Chunyu Liu, Minna Mannikko, Lorenz Risch, Jerome I Rotter, Harold Snieder, Juha Veijola, Alexandra I Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C Heath, Marjo-Riitta Jarvelin, Mika Kahonen, Sharon LR Kardia, Michael Kuhne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimaki, Andrew M McIntosh, Karen L Mohlke, Alanna C. Morrison, Nicholas G Martin, Albertine J. Oldehinkel, Brenda W.J.H. Penninx, Bruce M Psaty, Olli T Raitakari, Igor Rudan, Nilesh J Samani, Laura J. Scott, Tim D Spector, Niek Verweij, David R. Weir, James F Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D Bell, Paul Matthews, Adrian Rothenfluh, Sylvane Desrivieres, Gunter Schumann, Paul Elliott

Posted 30 Oct 2018
bioRxiv DOI: 10.1101/453332

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.

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