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Massively scalable genetic analysis of antibody repertoires

By Bryan Briney, Dennis R. Burton

Posted 19 Oct 2018
bioRxiv DOI: 10.1101/447813

With technical breakthroughs in the throughput and read-length of next-generation sequencing platforms, antibody repertoire sequencing is becoming an increasingly important tool for detailed characterization of the immune response. There is a need for open, scalable software for the genetic analysis of repertoire-scale antibody sequence data. To address this gap, we have developed the ab[x] package of software tools. There are three core components of the ab[x] toolkit, all of which are freely available: abcloud (github.com/briney/abcloud) for deployment and management of cloud computational resources; abstar (github.com/briney/abstar) for pre-processing, germline gene assignment and primary annotation of antibody sequence data; and abutils (github.com/briney/abutils) which provides utilities for interactive downstream analysis of antibody repertoire data.

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