Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,353 bioRxiv papers from 289,502 authors.
The genome-wide, multi-layered architecture of chromosome pairing in early Drosophila embryos
Jumana AlHaj Abed,
Bryan R. Lajoie,
Ruth B. McCole,
Son C. Nguyen,
Eric F. Joyce,
T. Niroshini Senaratne,
Mohammed A. Hannan,
Leonid A. Mirny,
Posted 17 Oct 2018
bioRxiv DOI: 10.1101/443028 (published DOI: 10.1038/s41467-019-12211-8)
Posted 17 Oct 2018
Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focused on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. We first addressed the long-standing question of whether pairing extends genome-wide and, to this end, developed a haplotype-resolved Hi-C approach that uses a new strategy to minimize homolog misassignment and thus robustly distinguish trans-homolog from cis contacts. This approach revealed striking genome-wide pairing in Drosophila embryos. Moreover, we discovered pairing to be surprisingly structured, with trans-homolog domains and interaction peaks, many coinciding with the positions of analogous cis features. We also found a significant correlation between pairing and the chromatin accessibility mediated by the pioneer factor Zelda. Our findings reveal a complex, highly structured organization underlying homolog pairing, first discovered more than a century ago.
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