Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 55,041 bioRxiv papers from 254,018 authors.
The genome-wide, multi-layered architecture of chromosome pairing in early Drosophila embryos
Jumana AlHaj Abed,
Bryan R. Lajoie,
Ruth B. McCole,
Son C. Nguyen,
Eric F. Joyce,
T. Niroshini Senaratne,
Mohammed A. Hannan,
Leonid A. Mirny,
Posted 17 Oct 2018
bioRxiv DOI: 10.1101/443028
Posted 17 Oct 2018
Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focused on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood. We first addressed the long-standing question of whether pairing extends genome-wide and, to this end, developed a haplotype-resolved Hi-C approach that uses a new strategy to minimize homolog misassignment and thus robustly distinguish trans-homolog from cis contacts. This approach revealed striking genome-wide pairing in Drosophila embryos. Moreover, we discovered pairing to be surprisingly structured, with trans-homolog domains and interaction peaks, many coinciding with the positions of analogous cis features. We also found a significant correlation between pairing and the chromatin accessibility mediated by the pioneer factor Zelda. Our findings reveal a complex, highly structured organization underlying homolog pairing, first discovered more than a century ago.
- Downloaded 829 times
- Download rankings, all-time:
- Site-wide: 7,888 out of 55,041
- In genetics: 618 out of 3,183
- Year to date:
- Site-wide: 6,274 out of 55,041
- Since beginning of last month:
- Site-wide: 23,117 out of 55,041
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!