Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 63,112 bioRxiv papers from 279,939 authors.
Genetic control of variability in subcortical and intracranial volumes
Dennis van der Meer,
Nhat Trung Doan,
Jan K Buitelaar,
Erlend S. Dørum,
Stephanie Le Hellard,
Erik G Jönsson,
Knut K. Kolskår,
Martina J. Lund,
Jan E. Nordvik,
Dominique de Quervain,
Olav B. Smeland,
Vidar M. Steen,
Ida E Sønderby,
Kristine M. Ulrichsen,
Ole A Andreassen,
Lars T. Westlye
Posted 15 Oct 2018
bioRxiv DOI: 10.1101/443549
Posted 15 Oct 2018
Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology to perform genome-wide association analysis of mean and variance in nine key brain features (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, intracranial volume and cortical thickness), integrating genetic and neuroanatomical data from a large lifespan sample (n=25,575 individuals; 8 to 89 years, mean age 51.9 years). We identify genetic loci associated with phenotypic variability in cortical thickness, thalamus, pallidum, and intracranial volumes. The variance-controlling loci included genes with a documented role in brain and mental health and were not associated with the mean anatomical volumes. This proof-of-principle of the hypothesis of a genetic regulation of brain volume variability contributes to establishing the genetic basis of phenotypic variance (i.e., heritability), allows identifying different degrees of brain robustness across individuals, and opens new research avenues in the search for mechanisms controlling brain and mental health.
- Downloaded 339 times
- Download rankings, all-time:
- Site-wide: 29,518 out of 63,112
- In neuroscience: 5,029 out of 11,288
- Year to date:
- Site-wide: 22,636 out of 63,112
- Since beginning of last month:
- Site-wide: 48,442 out of 63,112
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!