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Gene Expression Correlates of the Cortical Network Underlying Sentence Processing

By Xiang-Zhen Kong, Nathalie Tzourio-Mazoyer, Marc Joliot, Evelina Fedorenko, Jia Liu, Simon E. Fisher, Clyde Francks

Posted 11 Oct 2018
bioRxiv DOI: 10.1101/439984

A pivotal question in modern neuroscience is which genes regulate brain circuits that underlie cognitive functions. However, the field is still in its infancy. Here we report an integrated investigation of the high-level language network (i.e., sentence processing network) in the human cerebral cortex, combining regional gene expression profiles, task fMRI, and resting-state functional network approaches. We revealed reliable gene expression-functional network correlations using multiple datasets and network definition strategies, and identified a consensus set of genes related to connectivity within the sentence-processing network. The genes involved showed enrichment for neural development functions, as well as association signals with autism, which can involve disrupted language functioning. Our findings help elucidate the molecular basis of the brain's infrastructure for language. The integrative approach described here will be useful to study other complex cognitive traits.

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