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Condensin II inactivation in interphase does not affect chromatin folding or gene expression

By Nezar Abdennur, Wibke Schwarzer, Aleksandra Pekowska, Indra Alon Shaltiel, Wolfgang Huber, Christian H. Haering, Leonid A. Mirny, Fran├žois Spitz

Posted 07 Oct 2018
bioRxiv DOI: 10.1101/437459

Condensin complexes have been proposed to play a prominent role in interphase chromatin organization and control of gene expression. Here, we report that the deletion of the central condensin II kleisin subunit Ncaph2 in differentiated mouse hepatocytes does not lead to significant changes in chromosome organization or in gene expression. Both observations challenge current views that implicate condensin in interphase chromosomal domain formation and in enhancer-promoter interactions. Instead, we suggest that the previously reported effects of condensin perturbation may result from their structural role during mitosis, which might indirectly impact the re-establishment of interphase chromosomal architecture after cell division.

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