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Alzheimer′s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

By Bikash R. Sahoo, Takuya Genjo, Michael Bekier, Sarah J Cox, Andrea K. Stoddard, Magdalena Ivanova, Kazuma Yasuhara, Carol A. Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy

Posted 05 Oct 2018
bioRxiv DOI: 10.1101/435396 (published DOI: 10.1039/c8cc07921h)

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (~10 nm) and macro-nanodiscs (>15 nm) are used to study Abeta-1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Abeta and regulate its aggregation kinetics by trapping intermediates. Results demonstrating reduced neurotoxicity of nanodisc-bound Abeta oligomers are also reported.

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