Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,351 bioRxiv papers from 289,483 authors.

Transient patterns of functional dysconnectivity in youth with psychosis spectrum symptoms

By Eva Mennigen, Dietsje D. Jolles, Catherine E Hegarty, Mohan Gupta, Maria Jalbrzikowski, Loes M Olde Loohuis, Roel A. Ophoff, Katherine H Karlsgodt, Carrie E Bearden

Posted 25 Sep 2018
bioRxiv DOI: 10.1101/426932

Psychosis spectrum disorders are conceptualized as neurodevelopmental disorders accompanied by disruption of large-scale functional brain networks. Both static and dynamic dysconnectivity have been described in patients with schizophrenia and, more recently, in help-seeking individuals at clinical high-risk for psychosis. Less is known, however, about developmental aspects of dynamic functional network onnectivity (FNC) associated with psychotic symptoms (PS) in the general population. Here, we investigate resting state fMRI data using established dynamic FNC methods in the Philadelphia Neurodevelopmental Cohort (ages 8-22), including 129 participants experiencing PS and 452 participants without PS (non-PS). Applying a sliding window approach and k-means clustering, 5 dynamic states with distinct whole-brain connectivity patterns were identified. PS associated dysconnectivity was most prominent in states characterized by synchronization or antagonism of the default mode network (DMN) and cognitive control (CC) domains. Hyperconnectivity between DMN, salience, and CC domains in PS youth only occurred in a state characterized by synchronization of the DMN and CC domains, a state that also becomes less frequent with age. However, dysconnectivity of the sensorimotor and visual systems in PS youth was revealed in other transient states completing the picture of whole-brain dysconnectivity patterns associated with PS. Overall, state-dependent dysconnectivity was observed in PS youth, providing the first evidence that disruptions of dynamic functional connectivity are present across a broader psychosis continuum.

Download data

  • Downloaded 136 times
  • Download rankings, all-time:
    • Site-wide: 55,448 out of 65,351
    • In neuroscience: 9,858 out of 11,706
  • Year to date:
    • Site-wide: 53,446 out of 65,351
  • Since beginning of last month:
    • Site-wide: 52,895 out of 65,351

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)