Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)
By
Catherine John,
Nicola F Reeve,
Robert C Free,
Alexander T Williams,
Aliki-Eleni Farmaki,
Jane Bethea,
Linda M Barton,
Nick Shrine,
Chiara Batini,
Richard Packer,
Sarah Terry,
Beverley Hargadon,
Qingning Wang,
Carl A. Melbourne,
Emma L Adams,
Catherine E Bee,
Kyla Harrington,
José Miola,
Nigel J Brunskill,
Christopher E Brightling,
Julian Barwell,
Susan E Wallace,
Ron Hsu,
David J Shepherd,
Edward J Hollox,
Louise V Wain,
Martin D. Tobin
Posted 20 Sep 2018
bioRxiv DOI: 10.1101/422782
(published DOI: 10.1093/ije/dyz073)
EXCEED is a longitudinal population-based cohort which facilitates investigation of genetic, environmental and lifestyle-related determinants of a broad range of diseases and of multiple morbidity through data collected at baseline and via electronic healthcare record linkage. Recruitment has taken place in Leicester, Leicestershire and Rutland since 2013 and is ongoing, with 10 156 participants aged 30-69 to date. The population of Leicester is diverse and additional recruitment from the local South Asian community is ongoing. Participants have consented to follow-up for up to 25 years through electronic health records (EHR). Data available includes baseline demographics, anthropometry, spirometry, lifestyle factors (smoking and alcohol use) and longitudinal health information from primary care records, with additional linkage to other EHR datasets planned. Patients have consented to be contacted for recall-by-genotype and recall-by-phenotype sub-studies, providing an important resource for precision medicine research. We welcome requests for collaboration and data access by contacting the study management team via exceed@le.ac.uk.
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