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Distribution of duck-origin parvovirus in Cherry Valley ducks in vivo over time and histopathological investigation

By Bing Chen, Qihui Luo, Jing Xu, Chao Huang, Wentao Liu, An-chun Cheng, Zhengli Chen

Posted 17 Sep 2018
bioRxiv DOI: 10.1101/420067

In 2015, we successfully isolated a strain of duck-origin parvovirus from Cherry Valley ducks, which we denominated QH-L01. In this study, quantitative and localized duck-origin parvovirus in Cherry Valley ducks was examined by Real time fluorescence quantitative PCR (qPCR) and immunohistochemistry (IHC), and pathological damage to the tissues and organs was observed by hematoxylin-eosin staining (HE staining). qPCR showed that the viral load was higher in the spleen, brain, lung, cecum, ileum duodenum over time. The results from IHC indicated that positive reactions were detected in the hepatocytes, epithelium of the lung atrium, myocardial cells, goblet cells of the intestine, brain cells. Primary histological examinationrevealed pulmonary lobule depletion and dilation in the lung as well as necrosis and erosion of the villus tip in the duodenum, ileum and cecum. This study is the first demonstration that duck-origin parvovirus can be transmitted from the spleen to the brain and lung, resulting in proliferation and dissemination of the virus to the cecum, ileum, duodenum and other tissues through the blood; the lung, duodenum, ileum and cecum may thus represent the main target tissues and organs for the duck-origin parvovirus.

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