Does Neuroticism Cause Depression? A Mendelian Randomization Study
Maria S. Speed,
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium,
Anders D. Børglum,
Søren D. Østergaard
Posted 18 Sep 2018
bioRxiv DOI: 10.1101/420703
Posted 18 Sep 2018
Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression.
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