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Does Neuroticism Cause Depression? A Mendelian Randomization Study

By Doug Speed, Gibran Hemani, Maria S. Speed, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Anders D. Børglum, Søren D. Østergaard

Posted 18 Sep 2018
bioRxiv DOI: 10.1101/420703

Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression.

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