Using genetics to examine a general liability to childhood psychopathology
By
Lucy Riglin,
Ajay K Thapar,
Beate Leppert,
Joanna Martin,
Alexander Richards,
Richard Anney,
George Davey Smith,
Kate Tilling,
Evie Stergiakouli,
Benjamin B. Lahey,
Michael C O’Donovan,
Stephan Collishaw,
Anita Thapar
Posted 12 Sep 2018
bioRxiv DOI: 10.1101/409540
(published DOI: 10.1007/s10519-019-09985-4)
Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N=8161) and age 13 (N=7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. Schizophrenia, ADHD and depression PRS were also associated with specific factors but there was evidence for developmental changes. Funding This work was supported by the Wellcome Trust (204895/Z/16/Z).
Download data
- Downloaded 709 times
- Download rankings, all-time:
- Site-wide: 29,883
- In genetics: 1,520
- Year to date:
- Site-wide: 45,842
- Since beginning of last month:
- Site-wide: 104,612
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!