Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,719 bioRxiv papers from 278,291 authors.

Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general "p" factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N=8161) and age 13 (N=7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood "p" factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general "p" factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. Schizophrenia, ADHD and depression PRS were also associated with specific factors but there was evidence for developmental changes.

Download data

• Downloaded 499 times
• Download rankings, all-time:
  • Site-wide: 19,222 out of 62,719
  • In genetics: 1,287 out of 3,561
• Year to date:
  • Site-wide: 14,863 out of 62,719
• Since beginning of last month:
  • Site-wide: 21,897 out of 62,719

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide