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Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development

By Tomasz J. Nowakowski, Neha Rani, Mahdi Golkaram, Hongjun R Zhou, Beatriz Alvarado, Kylie Huch, Jay A West, Anne Leyrat, Alex A. Pollen, Arnold R. Kriegstein, Linda R. Petzold, Kenneth S. Kosik

Posted 09 Sep 2018
bioRxiv DOI: 10.1101/412510

MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development.

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