Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development
Tomasz J. Nowakowski,
Hongjun R Zhou,
Jay A West,
Alex A. Pollen,
Arnold R. Kriegstein,
Linda R. Petzold,
Kenneth S. Kosik
Posted 09 Sep 2018
bioRxiv DOI: 10.1101/412510
Posted 09 Sep 2018
MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development.
- Downloaded 912 times
- Download rankings, all-time:
- Site-wide: 13,343 out of 89,581
- In developmental biology: 290 out of 2,667
- Year to date:
- Site-wide: 40,376 out of 89,581
- Since beginning of last month:
- Site-wide: 36,105 out of 89,581
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!