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Association of SRB1, ITGB2 gene polymorphisms with coronary heart disease in Chinese Han population

By Yuan Sun, Tian Long-Wang, Yong Zeng, Feng-Ying Gong, Hui-Juan Zhu, Hui Pan, Ying Wang, Jia-Li Wang

Posted 29 Aug 2018
bioRxiv DOI: 10.1101/402792

Background: Previous studies in mice and humans have implicated the lipoprotein receptor SRB1 in association with atherosclerosis and lipid levels. In our previous proteomics research, the expression of ITGB2 has differences between epicardial and subcutaneous adipose tissue. However, the association between the reported variants and risk of coronary heart disease (CHD) was not confirmed. Methods: We conducted a case–control study consisted of 496 CHD patients and 367 controls. The two groups are adjusted for age, sex, body mass index, diabetes status and the proportion of dyslipidemia. The genotypes and allele frequency of variants rs838880, rs5888, rs5889 in SRB1 and rs235326, rs2070947, rs2070946 in ITGB2 were determined using Sequenom Mass-ARRAY technology. Results: The genotypes frequencies of all the six SNPs were consistent with Hardy-Weinberg Equilibrium test. For gene SRB1 rs838880, there was a significant difference in the alleles frequency (p=0.017), genotype frequency (p=0.0028), recessive model (p=0.000672) between CHD group and control group. For gene ITGB2 rs2070947, there was a significant difference in the recessive model (p=0.03). By comparing the clinical and serum metabolic indexes of SNP sites by genotype we find that among three genotypes of SRB1 rs5888, there were significant difference in the level of dyslipidemia history and serum LPA, among three genotypes of ITGB2 rs235236, there were significant difference in the levels of serum HDL, APOA1 and hypertension history, among three genotypes of ITGB2 rs2070947, there were significant difference in the level of serum APOA1, hsCRP. Conclusions: Our findings indicated that SNP rs838880 of gene SRB1 and rs2070947 of gene ITGB2 are associated with the risk of CHD in Chinese Han population.

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