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Counterbalancing the time-dependence effect on the human mitochondrial DNA molecular clock

By Vicente M. Cabrera

Posted 30 Aug 2018
bioRxiv DOI: 10.1101/404582

We propose a new method for estimating the coalescent age of phylogenetically related sequences that takes into account the observed time dependency of molecular rate estimates. Applying this method to human mitochondrial DNA data we have obtained significantly older ages for the main events of human evolution than in previous estimates. These ages are in close agreement with the most recent archaeological and paleontological records.

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