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PIRD: Pan immune repertoire database

By Wei Zhang, Longlong Wang, Ke Liu, Xiaofeng Wei, Kai Yang, Wensi Du, Shiyu Wang, Nannan Guo, Chuanchuan Ma, Lihua Luo, Jinghua Wu, Liya Lin, Fan Yang, Fei Gao, Xie Wang, Tao Li, Ruifang Zhang, Nitin K Saksena, Huanming Yang, Jian Wang, Lin Fang, Yong Hou, Xun Xu, Xiao Liu

Posted 25 Aug 2018
bioRxiv DOI: 10.1101/399493 (published DOI: 10.1093/bioinformatics/btz614)

Motivation T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database. Results We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualisation and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD. Availability and Implementation PIRD can be freely accessed at <https://db.cngb.org/pird>.

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