Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,230 bioRxiv papers from 306,637 authors.
The dynamic organization of genes inside the nucleus is an important determinant for their function. Using ultra-fast microscopy in S. cerevisiae cells and improved analysis of mean square displacements, we quantified DNA motion at time scales ranging from 10 milliseconds to minutes and found that following DNA damage, DNA exhibits distinct subdiffusive regimes. In response to double-strand breaks, chromatin is more mobile at large time scales but, surprisingly, its mobility is dramatically reduced at short time scales. This effect is even more pronounced at the break. Such pattern of dynamics is consistent with a global increase in chromatin persistence length following DNA damage. Scale-dependent nuclear exploration is regulated by the Rad51 repair protein, both at the break and throughout the genome. We propose a model in which stiffening of the damaged ends by the repair complex, combined with global increased stiffness, act like a needle in a decompacted ball of yarn, enhancing the ability of the break to traverse the chromatin meshwork.
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Downloads over time
Distribution of downloads per paper, site-wide
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