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BART: a transcription factor prediction tool with query gene sets or epigenomic profiles

By Zhenjia Wang, Mete Civelek, Clint L Miller, Nathan C. Sheffield, Michael J Guertin, Chongzhi Zang

Posted 12 Mar 2018
bioRxiv DOI: 10.1101/280982 (published DOI: 10.1093/bioinformatics/bty194)

Identification of functional transcription factors that regulate a given gene set is an important problem in gene regulation studies. Conventional approaches for identifying transcription factors, such as DNA sequence motif analysis, are unable to predict functional binding of specific factors and not sensitive to detect factors binding at distal enhancers. Here we present Binding Analysis for Regulation of Transcription (BART), a novel computational method and software package for predicting functional transcription factors that regulate a query gene set or associate with a query genomic profile, based on more than 6,000 existing ChIP-seq datasets for over 400 factors in human or mouse. This method demonstrates the advantage of utilizing publicly available data for functional genomics research.

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