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Cryo-EM structure of the polycystin 2-l1 ion channel

By Raymond E. Hulse, Zongli Li, Rick K. Huang, Jin Zhang, David E. Clapham

Posted 22 Mar 2018
bioRxiv DOI: 10.1101/287367 (published DOI: 10.7554/elife.36931)

We report the near atomic resolution (3.1 A) of the polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.

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