Architecture and dynamics of the jasmonic acid gene regulatory network
Richard J. Hickman,
Marcel C. Van Verk,
Anja J.H. Van Dijken,
Marciel Pereira Mendes,
Irene A. Vos,
Ivo Van Der Nagel,
Gert Jan Wesselink,
Michel de Vries,
Robert. C. Schuurink,
Corné M. J. Pieterse,
Saskia C.M. Van Wees
Posted 13 Dec 2016
bioRxiv DOI: 10.1101/093682 (published DOI: 10.1105/tpc.16.00958)
Posted 13 Dec 2016
The phytohormone jasmonic acid (JA) is a critical regulator of plant growth and defense. To significantly advance our understanding of the architecture and dynamics of the JA gene regulatory network, we performed high-resolution RNA-Seq time series analyses of methyl JA-treated Arabidopsis thaliana. Computational analysis unraveled in detail the chronology of events that occur during the early and later phases of the JA response. Several transcription factors, including ERF16 and bHLH27, were uncovered as early components of the JA gene regulatory network with a role in pathogen and insect resistance. Moreover, analysis of subnetworks surrounding the JA-induced transcription factors ORA47, RAP2.6L, and ANAC055 provided novel insights into their regulatory role of defined JA network modules. Collectively, our work illuminates the complexity of the JA gene regulatory network, pinpoints to novel regulators, and provides a valuable resource for future studies on the function of JA signaling components in plant defense and development.
- Downloaded 1,484 times
- Download rankings, all-time:
- Site-wide: 14,711
- In plant biology: 176
- Year to date:
- Site-wide: 134,863
- Since beginning of last month:
- Site-wide: 113,473
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!