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Host autophagosomes are diverted to a plant-pathogen interface

By Yasin Dagdas, Pooja Pandey, Nattapong Sanguankiattichai, Yasin Tumtas, Khaoula Belhaj, Cian Duggan, Maria Segretin, Sophien Kamoun, Tolga Osman Bozkurt

Posted 30 Jan 2017
bioRxiv DOI: 10.1101/102996

Filamentous plant pathogens and symbionts invade their host cells but remain enveloped by host-derived membranes. The mechanisms underlying the biogenesis and functions of these host-microbe interfaces are poorly understood. Recently, we showed that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host protein ATG8CL to stimulate autophagosome formation and deplete the selective autophagy receptor Joka2 from ATG8CL complexes. Here, we show that during P. infestans infection, ATG8CL autophagosomes are diverted to the pathogen interface. Our findings are consistent with the view that the pathogen coopts host selective autophagy for its own benefit.

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