Rxivist logo

Effects of Progesterone on the reproductive physiology in zebrafish

By Chunyun Zhong, Kewen Xiong, Xin Wang

Posted 07 Jun 2017
bioRxiv DOI: 10.1101/147280

Recent studies have investigated that the synthetic progestins may lead to health issues to the aquatic organisms. Progesterone is a steroidal progestin and has been used as a contraceptive drug, which is detected in the aquatic ecosystem. However, the potential effects of progesterone on the fish reproduction are largely unclear. Here, we tested the effects of progesterone on the fish reproductive and endocrine systems. Adult zebrafish were exposed to progesterone for 10 days at environmental concentrations. The production of eggs was reduced in the exposed fish, and the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish were significantly diminished. Our results suggested that progesterone may cause adverse health effects on fish by disrupting the endocrine system, and short-term exposure to progesterone could overt affect the fish reproduction.

Download data

  • Downloaded 1,291 times
  • Download rankings, all-time:
    • Site-wide: 8,058 out of 94,912
    • In pharmacology and toxicology: 49 out of 909
  • Year to date:
    • Site-wide: 22,090 out of 94,912
  • Since beginning of last month:
    • Site-wide: 26,069 out of 94,912

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)