Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,524 bioRxiv papers from 264,866 authors.

Human germline mutation and the erratic evolutionary clock

By Priya Moorjani, Ziyue Gao, Molly Przeworski

Posted 09 Jun 2016
bioRxiv DOI: 10.1101/058024 (published DOI: 10.1371/journal.pbio.2000744)

Our understanding of the chronology of human evolution relies on the "molecular clock" provided by the steady accumulation of substitutions on an evolutionary lineage. Recent analyses of human pedigrees have called this understanding into question, by revealing unexpectedly low germline mutation rates, which imply that substitutions accrue more slowly than previously believed. Translating mutation rates estimated from pedigrees into substitution rates is not as straightforward as it may seem, however. We dissect the steps involved, emphasizing that dating evolutionary events requires not "a mutation rate", but a precise characterization of how mutations accumulate in development, in males and females-knowledge that remains elusive.

Download data

  • Downloaded 1,037 times
  • Download rankings, all-time:
    • Site-wide: 6,118 out of 57,529
    • In evolutionary biology: 385 out of 3,943
  • Year to date:
    • Site-wide: 26,942 out of 57,529
  • Since beginning of last month:
    • Site-wide: 31,794 out of 57,529

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News