Transcriptomic atlas of mushroom development highlights an independent origin of complex multicellularity
By
Krisztina Krizsán,
Éva Almási,
Zsolt Merényi,
Neha Sahu,
Máté Virágh,
Tamás Kószó,
Stephen Mondo,
Brigitta Kiss,
Balázs Bálint,
Ursula Kües,
Kerrie Barry,
Judit Cseklye,
Botond Hegedűs,
Bernard Henrissat,
Jenifer Johnson,
Anna Lipzen,
Robin A. Ohm,
István Nagy,
Jasmyn Pangilinan,
Juying Yan,
Yi Xiong,
Igor V. Grigoriev,
David S. Hibbett,
László G. Nagy
Posted 18 Jun 2018
bioRxiv DOI: 10.1101/349894
We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly 300 conserved gene families and >70 functional groups contained developmentally regulated genes from five to six species, covering functions related to fungal cell wall (FCW) remodeling, targeted protein degradation, signal transduction, adhesion and small secreted proteins (including effector-like orphan genes). Several of these families, including F-box proteins, protein kinases and cadherin-like proteins, showed massive expansions in Agaricomycetes, with many convergently expanded in multicellular plants and/or animals too, reflecting broad genetic convergence among independently evolved complex multicellular lineages. This study provides a novel entry point to studying mushroom development and complex multicellularity in one of the largest clades of complex eukaryotic organisms.
Download data
- Downloaded 743 times
- Download rankings, all-time:
- Site-wide: 28,333
- In evolutionary biology: 1,425
- Year to date:
- Site-wide: 55,719
- Since beginning of last month:
- Site-wide: 83,785
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!