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Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to arctic sled dogs

By Xuan Wang, Bo-Wen Zhou, Ting-Ting Yin, Fang-Liang Chen, Ali Esmailizadeh, Melissa M Turner, Andrei D Poyarkov, Peter Savolainen, Guo-Dong Wang, Qiaomei Fu, Ya-Ping Zhang

Posted 19 Jun 2018
bioRxiv DOI: 10.1101/350512

Canine transmissible venereal tumor (CTVT), the oldest known somatic cell line, is a living fossil, originating from cancer cells transmitted from a host to other canids during the mating process. In the present study, we creatively used ancient genome analysis method to decipher the genetic component of the ancient founder of CTVT. The results showed that the CTVT founder came from an arctic sled dog population that possessed introgression from another species, coyote. It revealed that CTVT not only plays important role in cancer evolution study, but also can be treated as living fossils to study ancient evolutionary history of dogs.

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