Rxivist logo

Extensive Expansion of the Speedy gene Family in Homininae and Functional Differentiation in Humans

By Liang Wang, Hui Wang, Hongmei Wang, Yuhui Zhao, Xiaojun Liu, Gary Wong, Qinong Ye, Xiaoqin Xia, George F. Gao, Shan Gao

Posted 26 Jun 2018
bioRxiv DOI: 10.1101/354886

Background: The cell cycle plays important roles in physiology and disease. The Speedy/RINGO family of atypical cyclins regulates the cell cycle. However, the origin, evolution and function of the Speedy family are not completely understood. Understanding the origins and evolution of Speedy family would shed lights on the evolution of complexity of cell cycles in eukaryotes. Results: Here, we performed a comprehensive identification of Speedy genes in 258 eukaryotic species and found that the Speedy subfamily E was extensively expanded in Homininae, characterized by emergence of a low-Spy1-identify domain. Furthermore, the Speedy gene family show functional differentiation in humans and have a distinct expression pattern, different regulation network and co-expressed gene networks associated with cell cycle and various signaling pathways. Expression levels of the Speedy gene family are prognostic biomarkers among different cancer types. Conclusions: Overall, we present a comprehensive view of the Speedy genes and highlight their potential function.

Download data

  • Downloaded 487 times
  • Download rankings, all-time:
    • Site-wide: 68,300
    • In evolutionary biology: 3,485
  • Year to date:
    • Site-wide: 79,895
  • Since beginning of last month:
    • Site-wide: 56,176

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News