Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 55,054 bioRxiv papers from 254,092 authors.
Reduced signal for polygenic adaptation of height in UK Biobank
Jeremy J. Berg,
Nicholas A Sinnott-Armstrong,
Anja Moltke Joergensen,
Evan A Boyle,
Jonathan K Pritchard,
Posted 25 Jun 2018
bioRxiv DOI: 10.1101/354951 (published DOI: 10.7554/elife.39725)
Posted 25 Jun 2018
Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK Biobank (UKB), a large, independent dataset. We find that the signals of selection using UKB effect-size estimates for height are strongly attenuated or absent. We also provide evidence that previous analyses were confounded by population stratification Therefore, the conclusion of strong polygenic adaptation now lacks support. Moreover, these discrepancies highlight (1) that methods for correcting for population stratification in GWAS may not always be sufficient for polygenic trait analyses, and (2) that claims of differences in polygenic scores between populations should be treated with caution until these issues are better understood.
- Downloaded 4,825 times
- Download rankings, all-time:
- Site-wide: 359 out of 55,075
- In evolutionary biology: 8 out of 3,815
- Year to date:
- Site-wide: 506 out of 55,075
- Since beginning of last month:
- Site-wide: 5,218 out of 55,075
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!