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A Transcriptional Lineage of the Early C. elegans Embryo

By Sophia C Tintori, Erin Osborne Nishimura, Patrick Golden, Jason D Lieb, Bob Goldstein

Posted 08 Apr 2016
bioRxiv DOI: 10.1101/047746 (published DOI: 10.1016/j.devcel.2016.07.025)

During embryonic development, cells must establish fates, morphologies and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become possible to measure the full suite of transcripts in a single cell. Here we quantify the abundance of every mRNA transcript in each cell of the C. elegans embryo up to the 16-cell stage. We describe spatially dynamic expression, quantify cell-specific differential activation of the zygotic genome, and identify critical developmental genes previously unappreciated because of their partial redundancy. We present an interactive data visualization tool that allows broad access to our dataset. This genome-wide single-cell map of mRNA abundance, alongside the well-studied life history and fates of each cell, describes at a cellular resolution the mRNA landscape that guides development.

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