Rxivist logo

Impairment of zebrafish reproduction upon exposure to melengestrol acetate

By Kewen Xiong, Chunyun Zhong, Xin Wang

Posted 06 Jun 2017
bioRxiv DOI: 10.1101/146506

Synthetic progestins contamination is common in the aquatic ecosystem, which may lead to serious health problem on aquatic animals. Melengestrol acetate (MGA) has been detected in the aquatic environment; however, its potential effects on fish reproduction are largely unclear. Here, we aimed to investigate the endocrine disruption and impact of MGA on zebrafish reproduction. Six-month old reproductive zebrafish were exposed to four nominal concentrations of MGA (1, 10, 100 and 200 ng/L) for 15 days. Treatment with MGA reduced the egg production with a significant decrease at 200 ng/L. The circulating concentrations of estradiol and testosterone in female zebrafish or 11-keto testosterone in male zebrafish were significantly diminished compared to the non-exposed control fish. The early embryonic development or hatching rates were unaffected during the MGA exposure. Our results indicated that MGA was a potent endocrine disruptor in fish and the fish reproduction could be impaired even during a short-term exposure to MGA.

Download data

  • Downloaded 252 times
  • Download rankings, all-time:
    • Site-wide: 64,166 out of 94,912
    • In developmental biology: 1,985 out of 2,812
  • Year to date:
    • Site-wide: 87,187 out of 94,912
  • Since beginning of last month:
    • Site-wide: 90,036 out of 94,912

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)