Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,258 bioRxiv papers from 296,039 authors.

Feedback control of neurogenesis by tissue packing

By Tom W Hiscock, Joel B. Miesfeld, Kishore R Mosaliganti, Brian A Link, Sean G Megason

Posted 23 Jan 2018
bioRxiv DOI: 10.1101/252445 (published DOI: 10.1242/dev.157040)

Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Whilst many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that dense tissue packing and complex cell geometries play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, in regions of high cell density, progenitors are physically pushed away from the apical surface, which, in a Notch-dependent manner, leads to their differentiation. Using simulations we show that this naturally performs negative feedback control on cell number. Our results suggest a model whereby differentiation rate is carefully tuned to correct fluctuations in cell number, originating from variable cell cycle progression and inherently probabilistic differentiation programs.

Download data

  • Downloaded 410 times
  • Download rankings, all-time:
    • Site-wide: 26,633 out of 67,221
    • In developmental biology: 719 out of 1,998
  • Year to date:
    • Site-wide: 61,460 out of 67,221
  • Since beginning of last month:
    • Site-wide: 60,258 out of 67,221

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News